Found on the membrane of nerve cells, mu opioid receptors acts as a ‘middle-man’ to opioid analgesia, opioid tolerance and addiction. The Mu Opioid Receptor, often referred to as MOR, plays a important role in addiction process. As a member of the opioid receptor family, it is primarily found in the brain and spinal cord. To put it simply, this receptor is responsible for the effects of opioid drugs, both prescribed and illicit, on your body.
When opioids attach to the Mu Opioid Receptor, they activate a chain of events that result in pain relief, sedation and even feelings of euphoria. This provides an explanation for why opioids can be highly addictive. Over time, your body becomes dependent on these opioids and cravings for the drugs can become overpowering.
Understanding the Mu Opioid Receptor is fundamental for addiction treatment. Medications like methadone, buprenorphine and naloxone are used to target this receptor, helping to manage withdrawal symptoms and reduce cravings. By blocking the Mu Opioid Receptor, these medications can aid in the recovery process by alleviating discomfort and reducing the risk of relapse.
The Mu Opioid Receptor is not a recent discovery. It was identified and characterised back in the 1970s. Since then, scientists have continued to study this receptor to gain a better understanding of its function and develop more effective treatments for addiction.
Tolerance and Physical Dependence
Physical dependence can develop after 2 to 10 days of continuous opioid use with abrupt cessation leading to withdrawal syndrome. This syndrome, as per the ICD-10, is a group of symptoms emerging from the withdrawal of a substance after prolonged or high-dose use. Withdrawal symptoms include physiological disturbances and clinical manifestations like pain, autonomic symptoms (diarrhea, rhinorrhea, diaphoresis), central nervous system effects (sleeplessness, restlessness, tremors) and strong medication cravings. Addiction, a potential outcome of drug dependence, is marked by psychological and behavioural symptoms, including compulsive use and a high tendency to relapse after withdrawal.
Tolerance mechanisms show that high doses of opioids can lead to MOR (and DOR) internalization, necessitating greater opioid intake for the same effect due to fewer receptors. When opioids are removed (e.g., using an antagonist), the endogenous opioids fail to activate the remaining receptors.
Opioid therapy using MOR agonists raises concerns due to the potential for developing tolerance and physical dependence. Tolerance occurs when consistent stimulation of the MORs requires increasingly higher doses to achieve the same effect. In cancer patients receiving pain treatment, this tolerance is often due to escalating pain levels rather than the drugs themselves. Understanding the mechanisms behind tolerance and dependence is fundamental for managing opioid therapy effectively and developing new treatments. Research, including in vitro mutagenesis and receptor chimera analysis, focuses on specific domains and amino acid residues of the MOR to understand its function better.
Founded in 2008, WeDoRecover has evolved from an advisory service for addiction treatment into a comprehensive provider of care, following its 2019 merger with Changes Addiction Rehab in Johannesburg. Specialising in connecting patients to top-tier addiction treatment centers in the UK, South Africa and supporting individuals in recovery world wide.
Inpatient Rehab
Rehab care is a good option if you are at risk of experiencing strong withdrawal symptoms when you try stop a substance. This option would also be recommended if you have experienced recurrent relapses or if you have tried a less-intensive treatment without success.
Outpatient
If you're committed to your sobriety but cannot take a break from your daily duties for an inpatient program. Outpatient rehab treatment might suit you well if you are looking for a less restricted format for addiction treatment or simply need help with mental health.
Therapy
Therapy can be good step towards healing and self-discovery. If you need support without disrupting your routine, therapy offers a flexible solution for anyone wishing to enhance their mental well-being or work through personal issues in a supportive, confidential environment.
Mental Health
Are you having persistent feelings of being swamped, sad or have sudden surges of anger or intense emotional outbursts? These are warning signs of unresolved trauma mental health. A simple assesment by a mental health expert could provide valuable insights into your recovery.
Our network includes only the best rehab centers for personalised high quality addiction and mental health care. We guide you to a center that not only is a right fit for you or your loved one but that offers expert proven care and support. Start your healing today by choosing a rehab that cares about your recovery.