Peyote or Lophophora williamsii, is a small cactus with significant cultural and spiritual importance, especially in the southern United States and Mexico. It’s known for producing mescaline, a powerful hallucinogen used for centuries in Native American rituals for healing, divination and spiritual purposes.

Mescaline leads to hallucinogenic effects that vary based on dosage, previous hallucinogen use and the user’s emotional state. Effects usually begin within 1 to 2 hours of consumption and can last around 12 hours. Users may experience altered consciousness, visual and auditory hallucinations, introspective experiences and synesthesia, where senses intermingle. While some report feelings of peace and transcendence, others, especially those with mental illnesses, can face adverse reactions like prolonged psychosis, anxiety, confusion, depression and paranoia.

Regular Peyote use can lead to temporary tolerance, requiring higher doses for the same effects. Although it’s not typically regarded as physically addictive, psychological dependence, characterised by cravings and habitual use, can develop. Mescaline’s safety depends on various factors, including the dose and the user’s health and environment. Moderate doses are generally considered safe but higher doses might lead to severe psychological effects.

Legally, mescaline’s status is complex. In many countries, including the United States, it is illegal and classified as a Schedule I controlled substance, barring its use outside of specific religious contexts like the Native American Church. Its possession, sale or purchase can result in legal ramifications.

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